Fc-Gamma-RIIB Signaling in B-Cells

Description:

The ability of the immune system to respond appropriately to foreign antigen is dependent on a delicate balance of activating and inhibitory signals. Although positive signaling is essential for the generation of effective immunity, counterbalancing the immune response by inhibitory pathways is equally important. Loss of inhibitory signaling is often associated with autoreactivity and unchecked inflammatory responses, illustrating the essential role these systems play in immune regulation (Ref.1). Pairing of activation and inhib...

References:

Suppression of innate and adaptive B cell activation pathways by antibody coengagement of Fc?RIIb and CD19.
Szili D, Cserhalmi M, Bankó Z, Nagy G, Szymkowski DE, Sármay G.
MAbs. 2014 Jul-Aug;6(4):991-9. doi: 10.4161/mabs.28841. Epub 2014 Apr 23.
Targeting the Fc receptor in autoimmune disease.
Li X, Kimberly RP.
Expert Opin Ther Targets. 2014 Mar;18(3):335-50. doi: 10.1517/14728222.2014.877891. Review.
Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling.
Getahun A, Cambier JC.
Immunol Rev. 2015 Nov;268(1):66-73. doi: 10.1111/imr.12336. Review.
Acidic phospholipids govern the enhanced activation of IgG-B cell receptor.
Chen X, Pan W, Sui Y, Li H, Shi X, Guo X, Qi H, Xu C, Liu W.
Nat Commun. 2015 Oct 6;6:8552. doi: 10.1038/ncomms9552.

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Fc-Gamma-RIIB Signaling in B-Cells

Description:

References:

Suppression of innate and adaptive B cell activation pathways by antibody coengagement of Fc?RIIb and CD19.

Targeting the Fc receptor in autoimmune disease.

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling.

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor.

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Institutional License

Pathways

Fc-Gamma-RIIB Signaling in B-Cells

Description:

References:

Suppression of innate and adaptive B cell activation pathways by antibody coengagement of Fc?RIIb and CD19.

Targeting the Fc receptor in autoimmune disease.

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling.

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor.

Databases

Tools

Institutional License

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